|
rs10410711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several 19q13 single-nucleotide polymorphisms generalized the association of LOAD+P in a Caribbean Hispanic (CH) cohort, and the strongest signal was rs10410711 (pmeta = 5.1 × 10(-5)).
|
26359528 |
2015 |
|
rs10421862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant located 24 kb upstream of rs10410711 and rs10421862 was strongly associated with LOAD+P (pmeta = 1.0 × 10(-5)) in a meta-analysis of the CH cohort and an additional non-Hispanic Caucasian dataset.
|
26359528 |
2015 |
|
rs12965520
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics.
|
27805002 |
2016 |
|
rs1476679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The logistic regression reveals the C allele at rs1476679 is a protectiv</span>e factor for LOAD in the dominant model (OR = 0.779, 95%CI = 0.659-0.921, Pc = 0.009) adjusting for gender, age and APOE ε4 status.
|
26958812 |
2016 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease.
|
17385092 |
2007 |
|
rs17070145
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs17070145-T variant of the WWC1 gene, coding for the KIBRA protein, has been associated with both increased episodic memory performance and lowered risk for late onset Alzheimer's disease, although the mechanism behind this protective effect has not been completely elucidated.
|
28380666 |
2017 |
|
rs17070145
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We genotyped rs17070145 and 14 additional SNPs in 2571 late onset Alzheimer's disease (LOAD) patients vs. 2842 controls, including African-Americans.
|
21185624 |
2011 |
|
rs2569987
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The significant variants present only in CE and TC from LOAD are UNG rs2569987 and POLβ rs1012381950, respectively.
|
31415677 |
2019 |
|
rs80001089
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is also significant epistatic relationship (p = 0.0410) between UNG rs80001089 and NEIL1 rs7182283 in TC from LOAD subjects.
|
31415677 |
2019 |
|
rs137875858
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts (odds ratio = 2.15, Pmeta = 0.0095).
|
25419706 |
2014 |
|
rs137875858
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we show that overexpression of wild-type UNC5C causes low-grade death, which is intensified by an AD-linked mutation T835M.
|
27068745 |
2016 |
|
rs12344615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, a single nucleotide polymorphism (SNP, A-->G) in intron 8 of UBQLN 1 at the rs12344615 site (UBQ-8i) on chromosome 9q22 was associated with a higher risk of late-onset Alzheimer's disease (AD).
|
20350585 |
2010 |
|
rs2651206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, rs2651206 polymorphism was still strongly associated with LOAD (OR=0.72, P=0.05) after adjusted for age, gender, and the apolipoprotein E (APOE) ɛ4 status.
|
21219968 |
2011 |
|
rs7764257
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent large study has identified significant association of two single nucleotide polymorphisms (SNPs) (rs2651206 and rs7764257) in the TTBK1 gene with late-onset Alzheimer's disease (LOAD) in Spanish.
|
21219968 |
2011 |
|
rs3747742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, our findings support rs3747742-C as a protective factor for LOAD, especially in APOE ε4 carriers.
|
26797517 |
2017 |
|
rs2234256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified significant LOAD risk association with p.L211P (p=0.01, OR=1.27, 95%CI=1.05-1.54) and suggestive association with p.W191X (p=0.08, OR=1.35, 95%CI=0.97-1.87).
|
25886450 |
2015 |
|
rs2234258
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified significant LOAD risk association with p.L211P (p=0.01, OR=1.27, 95%CI=1.05-1.54) and suggestive association with p.W191X (p=0.08, OR=1.35, 95%CI=0.97-1.87).
|
25886450 |
2015 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our findings suggest that the rs75932628-T variant of TREM2 is an important risk factor for LOAD in the Colombian population.
|
30222607 |
2019 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We did not find an association between the rs75932628</span> single nucleotide polymorphism of TREM2 and LOAD in this study.
|
29256968 |
2018 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population.
|
24725293 |
2014 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Only the rs75932628-T variant (predicted to cause an R47H substitution) conferred a significant risk for early-onset AD (OR, 4.07; 95% CI, 1.3 to 16.9; p = 0.009).
|
23380991 |
2013 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Here, we present more evidence for the association of the R47H with LOAD risk in a Caucasian population comprising 4567 LOAD cases and controls.
|
26058841 |
2015 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Recent works have demonstrated a rare functional variant (R47H) in triggering receptor expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase susceptibility to late-onset Alzheimer's disease (AD), with an odds ratio similar to that of the apolipoprotein E ε4 allele.
|
23407992 |
2013 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular basis of R47H TREM2 loss of function is an emerging area of TREM2 biology.
|
29794134 |
2018 |
|
rs75932628
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease.
|
30185230 |
2018 |